Injectable magnesium oxychloride cement foam (MOCF)-derived scaffold for treating osteoporotic bone defects
AssigneeThe Chinese University of Hong Kong
InventorsTo Ngai, Yuwei Zhu, Ling Qin, Jiankun Xu
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Abstract
Provided herein are magnesium oxychloride cement compositions having a micro-/macro-two-tier porous structure derived from a Pickering foam form of the compositions. The compositions include magnesium oxide, magnesium chloride, water, and one or more surface modifying agents that modify at least a portion of the magnesium oxide, thereby creating particulates sufficient for stabilizing the Pickering foam. Also provided are bone repair scaffolds, and methods for producing the provided compositions and scaffolds and using them to repair bone defects.
Claims14
A composition having a form of a Pickering foam and comprising:
- 15 wt % to 70 wt % magnesium oxide;
- 2 wt % to 10 wt % magnesium chloride;
- 0.2 wt % to 2 wt % of a surface modifying agent;
- a calcium posphate cement, wherein the calcium posphate cement is calcium-deficient hydroxyapatite, hydroxyapatite, or brushite;
- and
- 20 wt % to 65 wt % water;
- wherein the identity and amount of the surface modifying agent are effective to modify at least a portion of the magnesium oxide, thereby creating particulates sufficient to stabilize the composition in the form of the Pickering foam.
Dependencies are inferred from the claim text.