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US 12,758,661 B2Granted
Steam sterilization of hydrogels crosslinked by beta-eliminative linkers
AssigneeProLynx LLC
InventorsJeffrey C. Henise, Gary W. Ashley, Brian Yao
Life of this patent
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Abstract
Methods for the steam sterilization of hydrogels crosslinked with a beta-eliminative linker without the drawback of significant degradation are provided.
Claims20
A method to sterilize a hydrogel linked with a cross-linker that degrades by beta elimination, which method comprises
- heating said hydrogel at a temperature of up to about 121 °C for up to 1 hour in a medium having a pH of between 2 and 4.
A hydrogel comprising a cross-linker degradable by a beta-elimination mechanism that has been sterilized by heating the hydrogel at a temperature up to about 121 °C in a medium having a pH between 2 and 4.
Dependencies are inferred from the claim text.