Double-component gastric ultrasound examination aided developer and preparation method therefor

A double-component gastric ultrasound examination aided developer, consisting of two components,

• a component A consists of functionalized silica particles, a defoamer, a preservative, sodium alginate, citric acid and water;
• and
• a component B is a calcium chloride solution,
• wherein a density of the functionalized silica particles is the same as a liquid density of the component A;
• the functionalized silica particles are biocompatible polymer modified silica particles, which are 0.5-1.5% by mass of the component A;
• in the biocompatible polymer modified silica particles, a diameter size of silica is 70-90 meshes,
• the biocompatible polymer is one or more of polyethylene glycol, branched polyethylene glycol, chitosan and hyaluronic acid;
• the biocompatible polymer is modified by grafting of an aldehyde group and prolamin, or grafting of a sulfydryl group and prolamin, a grafting rate of the aldehyde group or the sulfydryl group occupies 10-20% of an active group of the biocompatible polymer, and a grafting rate of the prolamin occupies 5-10% of the active group of the biocompatible polymer;
• active groups of polyethylene glycol and branched polyethylene glycol are hydroxyl groups, the active group of the chitosan is an amino group, and the active group of the hyaluronic acid is a carboxyl group;
• sodium alginate is 0.5-1% by mass of the component A, and a viscosity of an 1% sodium alginate aqueous solution is 100-200 mPa·s;
• citric acid is 4.2-6% by mass of the component A;
• a concentration of the calcium chloride solution in the component B is 12.5-18% by mass;
• a volume ratio of the component A to the component B in the double-component gastric ultrasound examination aided developer is 9:1;
• and
• a mass ratio of citric acid to calcium chloride in the double-component gastric ultrasound examination aided developer is 3:1.