Linker peptide, FVIII protein or variant thereof containing linker peptide, and use thereof
AssigneeShenzhen Syno Minicircle Biotechnology Co., Ltd.
InventorsPing Chen, Jie Liu, Xiaohu Hou, Guochuang Chen, Zhiying Chen
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Abstract
A connecting peptide, a coagulation factor 8 protein containing the connecting peptide or a variant thereof and uses thereof, and belongs to the field of gene defect treatment drugs. The connecting peptide can improve the expression level, activity and therapeutic effect of coagulation factor eight protein or its variants using microcircle DNA as a carrier, and also has good secondary administration therapeutic effect, and has good safety and can be used in long-term expression in vivo and other advantages.
Claims3
A coagulation factor VIII (FVIII) protein comprising a linker peptide connecting A1-A2 domains with A3-C1-C2 domains;
- wherein the linker peptide of the FVIII protein comprising the amino acid sequence as shown in SEQ ID NO. 1 or SEQ ID NO. 2.
Dependencies are inferred from the claim text.