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US 12,758,645 B2Granted
Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen
AssigneeSynaffix B.V.
InventorsLianne Lelieveldt, Remon van Geel, Sander Sebastiaan van Berkel, Floris Louis van Delft
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Abstract
The present invention provides antibody-conjugates for targeting CEA-expressing cells, in particular tumor cells. The invention further provides methods for preparing the antibody-conjugates, compositions thereof, and methods of using the same.
Claims7
An antibody-conjugate according to general structure (1):
- AB-[(L6)b-{Z-L-D}x]y (1)
- wherein:
- AB is an anti-CEA antibody comprising a light chain and a heavy chain comprising the amino acid sequences set forth in SEQ ID NO:
- 38 and 36, respectively;
- L6 is -GlcNAc(Fuc)w-S—;
- S is GalNAc;
- GlcNAc is N-acetylglucosamine;
- Fuc is fucose;
- w is 0 or 1;
- b is 0 or 1;
- x is 1 or 2;
- y is 1, 2, 3 or 4;
- -Z-L-D is:
- wherein * is the point of attachment of -Z-L-D to L6,
- or a pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.