Biocompatible material and methods for making and using the same

A composition comprising at least a first polymer having a first reactive group and at least a second polymer having a second reactive group,

• wherein, said first polymer have an intrinsic viscosity [η] of at least 500 ml/g, said second polymer have an intrinsic viscosity [η] lower than the first polymer and less than 1800 ml/g,
• said first polymer's concentration in said composition is at most about 5 mg/ml,
• wherein said first polymer and/or said second polymer is independently selected from the group consisting of a polysaccharide, a poly (acrylic acid), a poly (hydroxyethylmethacrylate), an elastin, a collagen, a polyethylene glycol, a derivative thereof, and any combinations thereof,
• wherein said first reactive group is selected from the group consisting of a vinyl, an acryloyl, a thiol, an alkene, a thiolester, an isocyanate, an isothiocyanate, an alkyl halide, a sulfonyl halide, an epoxide, an imidoester, a fluorophenyl ester, a carbonate, a carbodiimide, a disulfide, an aziridine and any combinations thereof, and
• wherein said second reactive group is selected from the group consisting of a thiol, an amine, an azide, a hydrazide, a diene, a hydrazine, a hydroxylamine and any combinations thereof.