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US 12,758,629 B2Granted
N-aryl sulfonamide derivatives as vaccine adjuvant
AssigneeThe Regents of the University of California
InventorsDennis A. Carson, Tomoko Hayashi, Maripat Corr, Howard B. Cottam, Nikunj Shukla, Michael Chan
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Abstract
Bis-aryl sulfonamide compounds and methods of using those compounds, e.g., in a method of enhancing or prolonging an immune response, are provided. For example, the compounds may be employed with a vaccine and optionally at least one other adjuvant and/or one or more TLR ligands, at least one MAP kinase inhibitor, or any combination thereof.
Claims3
A compound of formula (II)
- wherein each n is an integer from 1 to 4;
- wherein R1 is independently selected from the group consisting of halogen, nitro, azido, hydroxyl, amino, C1-10-alkylamino, —CF3, carboxylic acid, and —O(C1-C6 alkyl);
- and
- wherein R2 is independently selected from the group consisting of halogen, nitro, azido, hydroxyl, amino, C1-10-alkylamino, —CF3, carboxylic acid, and —O(C2-C6 alkyl);
- wherein R3 is -L1-G,
- L1 is a divalent linker consisting of C1-C6 alkylene, C6-10-arylene, C1-C6 alkylene-amino, C1-C6 alkylene-amido, C1-C6 alkylene-ether, C1-C6 alkylene-ester, and combinations thereof, and
- G is
- or a salt thereof.
5 more elements
A compound having the structure:
Dependencies are inferred from the claim text.