Zika virus polypeptides
AssigneeMayo Foundation for Medical Education and Research
InventorsGregory A. Poland, Inna G. Ovsyannikova, Richard B. Kennedy
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Abstract
This document provides methods and materials related to selected Zika virus polypeptides. For example. vaccine compositions that contain one or more selected Zika virus polypeptides provided herein and that have the ability to increase immune responses against flaviviruses such as Zika viruses within a mammal (e.g., a human) are provided.
Claims22
A composition comprising at least four polypeptides, wherein each of said at least four polypeptides is a polypeptide consisting of the amino acid sequence set forth in any one of SEQ ID NOs:
- 1-17, and wherein at least one of said at least four polypeptides is covalently conjugated to a stabilizer selected from the group consisting of sucrose, lactose, a monosodium salt of glutamic acid, human serum albumin, and gelatin.
A composition comprising at least four polypeptides, wherein each of said at least four polypeptides is a polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs:1-17, and wherein at least one of said at least four polypeptides is embedded on the surface of a nanoparticle.
A method for increasing an immune response against a flavivirus in a mammal, wherein said method comprises administering to said mammal a composition comprising at least four polypeptides, wherein each of said at least four polypeptides is a polypeptide consisting of the amino acid sequence set forth in any one of SEQ ID NOs:1-17, and wherein at least one of said at least four polypeptides is covalently conjugated to a stabilizer selected from the group consisting of sucrose, lactose, a monosodium salt of glutamic acid, human serum albumin, and gelatin.
A method for increasing an immune response against a flavivirus in a mammal, wherein said method comprises administering to said mammal a composition comprising at least four polypeptides, wherein each of said at least four polypeptides is a polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs:1-17, and wherein at least one of said at least four polypeptides is embedded on the surface of a nanoparticle.
Dependencies are inferred from the claim text.