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US 12,758,620 B2Granted
Pharmaceutical composition containing insulin-like growth factor-2 and use thereof
AssigneeShanghai Institute of Nutrition and Health, Chinese Academy of Sciences
InventorsYufang Shi, Ying Wang, Liming Du, Liangyu Lin
Life of this patent
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Abstract
Provided is the use of an insulin-like growth factor-2 for preparing a pharmaceutical composition, wherein the pharmaceutical composition is used for (i) promoting the expression of the macrophage PD-L1, and/or (ii) inhibiting the expression of the macrophage IL-β. Also provided is a pharmaceutical composition containing insulin-like growth factor-2 as an active ingredient.
Claims6
A method of promoting differentiation of regulatory T cell;
- and inhibiting differentiation of Th1 cell and/or Th17 cell, comprising a step of:
- administering a macrophage treated with insulin-like growth factor-2 (IGF-2) or an active fragment having amino acids from position 25 to position 91 of IGF-2, to a subject;
- wherein the macrophage is cultured in the presence of IGF-2 or the active fragment to obtain the macrophage treated with the IGF-2 or the active fragment;
- and in the macrophage, the PD-L1 expression is up-regulated and/or the IL-1β expression is down-regulated.
1 more element
A method of treating a subject having an autoimmune disease, comprising a step of:
- administering a macrophage treated with insulin-like growth factor-2 (IGF-2) or an active fragment having amino acids from position 25 to position 91 of IGF-2, to the subject;
- wherein the macrophage is cultured in the presence of IGF-2 or the active fragment to obtain the macrophage treated with the IGF-2 or the active fragment;
- and in the macrophage, the PD-L1 expression is up-regulated and/or the IL-1β expression is down-regulated.
Dependencies are inferred from the claim text.