System providing safety architure for insulin dosing algorithm

A system for providing a long-acting or ultra-long-acting insulin adjustment day dose recommendation (ADDR) for a subject to treat diabetes mellitus, wherein the system comprises one or more processors and a memory, the memory comprising:

• instructions that, when executed by the one or more processors, perform a method responsive to receiving a dose guidance request (DGR), the instructions comprising:
• (A) obtaining a first data structure, comprising:
• (i) a glucose upper target range level (UTR) of the subject, and
• (ii) a glucose lower target range level (LTR) of the subject;
• (B) obtaining a second data structure, comprising:
• (i) a current dose guidance baseline (DGB), and
• (ii) a corresponding DGB timestamp representing when the DGB was made,
• wherein the current DGB corresponds to (a) a most recent ADDR, or (b) a starting basal dose (SBD);
• (C) obtaining a first data set, comprising a plurality of glucose measurements of the subject taken over a time course and thereby establish a blood glucose history (BGH), each respective glucose measurement in the plurality of glucose measurements comprising:
• (i) a blood glucose (BG) level, and
• (ii) a corresponding blood glucose timestamp (BGT) representing when in the time course the respective glucose measurement was made;
• (D) obtaining a second data set, comprising a basal insulin injection history (IH) of the subject, wherein the injection history comprises a plurality of injections during all or a portion of the time course and, for each respective injection in the plurality of injections comprising:
• (i) a corresponding injection amount (IA), and
• (ii) an injection timestamp (IT) representing when in the time course the respective injection occurred;
• (E) obtaining a third data structure, comprising an injection data refresh timestamp (IDR) for the subject;
• and
• (F) evaluating the first data structure, the second data structure, the third data structure, the first data set, and the second data set and thereby determine whether they collectively contain a set of evaluation information, comprising:
• (i) the glucose upper and lower target range levels of the subject,
• (ii) the current dose guidance baseline and the corresponding timestamp,
• (iii) the injection history refresh timestamp for the subject,
• (iv) the plurality of glucose measurements of the subject taken over the time course, and
• (v) the injection history of the subject;
• wherein:
• when a determination is made that the first data structure, the second data structure, the third data structure, the first data set, and the second data set collectively do contain the set of evaluation information, and when the dose guidance request was received within a given time limit from the injection data refresh timestamp, the method further comprises providing the long-acting or ultra-long-acting insulin ADDR, the recommendation being calculated based on data from the first data structure, the second data structure, the first data set, and the second data set, or
• when a determination is made that the first data structure, the second data structure, the third data structure, the first data set, and the second data set fail to collectively contain the set of evaluation information, or when the dose guidance request was received after the given time limit from the injection history refresh timestamp, no long-acting or ultra-long-acting insulin ADDR is provided.