Method of treating viral infections with NK cells treated with PM21 particles
AssigneesResearch Institute At Nationwide Children's Hospital, University of Central Florida Research Foundation, Inc.
InventorsAlicja Copik, Jeremiah Oyer, Nitin Chakravarti, Dean Anthony Lee
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Abstract
Disclosed are compositions and methods for directing NK cells to the bone marrow through the use of PM21 particles.
Claims3
A method of treating a viral infection associated with the bone marrow in a subject comprising contacting NK cells in vitro or ex vivo with one or more of plasma membrane particles expressing IL-21 and 41BBL on their surface (PM21 particles) and/or feeder cells expressing IL-21 on their surface (FC21 feeder cells) for 6 to 40 days, wherein the contacting induces a cellular mechanism within NK cells to induce fucosylation of P-selectin glycoprotein ligand-1 (PSGL-1) on the NK cells' surface, and adoptively transferring the NK cells to the subject.
Dependencies are inferred from the claim text.