Compositions for treating heart disease by inhibiting the action of mAKAP-β
AssigneeAnchored RSK3 Inhibitors, LLC
InventorsMichael S. Kapiloff, Jinliang Li, Michael Kritzer
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Abstract
The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAPβ, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAPβ binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
Claims20
A viral-based gene therapy vector encoding a fragment of a muscle A-kinase anchoring protein β (mAKAPβ) amino acid sequence, wherein said fragment consists of a p90 ribosomal S6 kinase type 3 (RSK3) binding domain that is at least 80% homologous to amino acids 1696-1835 of SEQ ID NO:
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Dependencies are inferred from the claim text.