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US 12,758,610 B2Granted
Methods and compositions comprising a CT20 peptide
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorsAnnette Khaled, Jesus Manuel Perez, Rania Bassiouni, Amanda Cox, Ana Martini
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Abstract
Disclosed herein are compositions comprising a CT20 peptide and methods of using the disclosed compositions to treat cancers expressing chaperonin containing TCP (CCT).
Claims18
A method of treating a subject having breast cancer or lung cancer, the method comprising:
- a) obtaining a blood sample from the subject;
- b) measuring the amount of chaperonin containing TCP (CCT) in the blood sample;
- c) determining that the subject has breast cancer or lung cancer if the amount of CCT in the blood sample is higher than an amount of CCT in a reference control of healthy blood;
- and
- d) initiating a therapeutic regime if the subject is determined as having breast cancer or lung cancer,
- wherein the therapeutic regimen comprises administering to the subject an effective amount of a composition comprising a CT20 peptide, wherein the CT20 peptide comprises the amino acid sequence of SEQ ID NO:
- 1.
4 more elements
A method of treating breast cancer or lung cancer in a subject, comprising
- a) obtaining a blood sample from the subject,
- b) contacting the blood sample with one or more CCT-targeting affinity reagents thereby capturing the cells bound by the one or more CCT-targeting affinity reagents,
- c) determining if the captured cells of step b) comprise circulating tumor cells, and
- d) administering to the subject a therapeutically effective amount of a cancer therapeutic agent if two or more circulating tumor cells are captured
- wherein the therapeutic regimen comprises administering to the subject an effective amount of a composition comprising a CT20 peptide, wherein the CT20 peptide comprises the amino acid sequence of SEQ ID NO:
- 1.
3 more elements
Dependencies are inferred from the claim text.