Recombinant bacteria producing chemicals inhibitory to Salmonella invasion
AssigneeCornell University
InventorCraig Altier
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Abstract
The present disclosure is directed to genetically modified bacteria that produce a diffusible signal factor (DSF). The disclosure also provides methods for treating or preventing Salmonella infection/invasion in a subject. The disclosure further provides vectors and compositions for carrying out the methods disclosed herein.
Claims27
A genetically engineered bacterium, wherein the genetically engineered bacterium comprises an exogenous nucleic acid encoding an enzyme that introduces a cis-2 double bond to a fatty acid, thereby producing a diffusible signal factor (DSF), wherein the nucleic acid encoding the enzyme is codon-optimized for expression in the genetically engineered bacterium, and wherein the genetically engineered bacterium is a probiotic bacterium, wherein the probiotic bacterium is selected from the group consisting of genera Escherichia, Propionibacterium, Lactobacillus, Bifidobacterium, and Streptococcus.
Dependencies are inferred from the claim text.