Water-activated mucoadhesive compositions to reduce intestinal absorption of nutrients
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsJeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Abstract
This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.
Claims16
A method of treating a subject, the method comprising administering to the subject a water-based, mucoadhesive composition comprising an aluminum-crosslinked sulfated agent, wherein the composition provides a continuous protective coating on healthy mucosa of at least a portion of the gastrointestinal tract of the subject to thereby modulate nutritional absorption by the subject.
Dependencies are inferred from the claim text.