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US 12,758,569 B2Granted
Treatment of RNA virus infection with a cytidine deaminase inhibitor
AssigneeThe Cleveland Clinic Foundation
InventorsYogen Saunthararajah, Babal K. Jha, Xiaorong Gu
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Abstract
The present invention provides compositions, systems, kits, and methods for treating a subject with an RNA virus infection (e.g., SARS-COV-2) by administering or providing a composition comprising a cytidine deaminase inhibitor (e.g., tetrahy-drouridine or cedazuridine).
Claims12
A method of treating a subject infected with an RNA virus without suppressing immunity comprising:
- administering a composition to lungs of a subject via said subject's airway, or providing said composition to said subject such that said subject administers said composition to said lungs themselves via said airway;
- wherein said lungs have non-dividing epithelial cells infected with SARS-COV-2 or other coronavirus;
- wherein said composition is non-immuno-suppressing and comprises a cytidine deaminase inhibitor.
Dependencies are inferred from the claim text.