Compositions for the treatment of fibrosis
AssigneeViking Therapeutics, Inc.
InventorsBrian Lian, Hiroko Masamune, Geoffrey E. Barker
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Abstract
The present disclosure is directed to methods of treating fibrotic conditions by administration of TRβ agonists. The disclosure provides methods wherein the abnormal deposition of extracellular matrix components, such as collagen, keratin, or elastin, is reduced, either through interaction of TRβ agonists with TGF-β—dependent inflammatory pathways, or by other mechanisms, thereby ameliorating fibrotic symptoms.
Claims17
A method of treating fibrosis, a fibrotic condition or a fibrotic symptom in a subject in need thereof comprising administering to said subject in need thereof a compound having the structure:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.