Methods and compositions for the treatment of traumatic brain injury (TBI) and related disorders
OwnerAkhil Mehrainventor
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Abstract
The present invention relates to methods for the treatment or prevention of symptoms associated with traumatic brain injury (TBI) and related disorders. The present disclosure provides compositions and methods for preventing, ameliorating, or alleviating neuropsychiatric symptoms and psychiatric disorders associated with TBI and related disorders consisting of administering a matrix-type transdermal patch with a composition consisting of opipramol, excluding any other component such as a pharmaceutical carrier or excipient.
Claims9
A method of treating post-concussive syndrome in a human subject who has sustained a concussion, comprising:
- administering to the human subject a therapeutically effective amount of a pharmaceutical composition comprising opipramol,
- wherein the post-concussive syndrome comprises at least one symptom selected from anxiety, irritability, cognitive dysfunction, insomnia, sleep disturbance, difficulty concentrating, difficulty remembering, fatigue, drowsiness, or a combination thereof,
- wherein the administering ameliorates the at least one symptom, and
- wherein the administering is initiated within seven days of the concussion or within seven days of appearance of the at least one symptom.
A method of treating post-concussive syndrome in a human subject who has sustained a concussion, comprising:
- sublingually administering to the human subject a therapeutically effective amount of a pharmaceutical composition comprising opipramol,
- wherein the post-concussive syndrome comprises at least one symptom selected from anxiety, irritability, cognitive dysfunction, insomnia, sleep disturbance, difficulty concentrating, difficulty remembering, fatigue, drowsiness, or a combination thereof,
- wherein the sublingual administration ameliorates the at least one symptom, and
- wherein the sublingual administration is initiated within seven days of the concussion or within seven days of appearance of the at least one symptom.
Dependencies are inferred from the claim text.