Back to results
US 12,758,554 B2Granted
Stable immediate release tablet and capsule formulations of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
AssigneePfizer R&D UK Limited
InventorsAndrew Richard Barrett, Ian Leonard Smales, Rand Dhiyaa Turki, Suet Mei Wong
Life of this patent
Estimating the term…
Abstract
The present invention is directed to new stable immediate release tablet and capsule formulations for the Janus Kinase 3 (JAK3) inhibitor 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one para-toluenesulfonate having structure
Claims3
A stable immediate release formulation comprising about 15-67% 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one para-toluenesulfonate salt, about 12-40% microcrystalline cellulose, about 12-40% lactose monohydrate, about 2-4% crospovidone;
- and about 3-10% glyceryl dibehenate, wherein the formulation has 0.7% w/w or less of a dimer of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one at 25-30° C./10-65% relative humidity for at least one year, wherein the stable immediate release formulation is free of, or comprises no more than 1.00% of magnesium stearate.
Dependencies are inferred from the claim text.