Suspension of triazole antifungal drug for atomizer
AssigneeShanghai Sheo Pharma Co. Ltd.
InventorsFang Jin, Xiaopei Lian, Cuicui Guo
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Abstract
Provided are a suspension of a triazole antifungal drug for an atomizer, and a preparation method therefor. The pH of the suspension is 3-8. The suspension comprises a triazole antifungal drug, a surfactant, an osmotic pressure regulator, a metal complexing agent, a pH regulator and water, wherein the triazole antifungal drug has a D50 diameter of 1-10 μm, and accounts for 0.025%-1% of the total mass of the suspension, and the mass ratio of the triazole antifungal drug to the surfactant is 1:1-50:1.
Claims15
A suspension of triazole antifungal drug for atomizer, with a pH value of 3~8, comprising a triazole antifungal drug, a surfactant, an osmotic pressure regulator, a metal complexing agent, a pH regulator and water;
- wherein the triazole antifungal drug has a D50 of 1~10 μm, an amount of the triazole antifungal drug is 0.025%~1% based on a total mass of the suspension, and a mass ratio of the triazole antifungal drug to the surfactant is 1:1~50:1;
- wherein the surfactant is one or more selected from the group consisting of non-ionic surfactants and amphoteric surfactants,
- the non-ionic surfactant is one or more selected from the group consisting of dehydrated sorbitol monolaurate, polyoxyethylene dehydrated sorbitol monolaurate, polyoxyethylene dehydrated sorbitol monooleate, polysorbates, polyoxyethylene castor oil, poloxamer, glycerol, polyethylene glycol 400, oleyl polyoxyethylene (2) ether, stearyl polyoxyethylene (2) ether, lauryl polyoxyethylene (4) ether, ethylene oxide and propylene oxide block copolymers, diethylene glycol dioleate, tetrahydrofurfuryl oleate, ethyl oleate, glycerol monooleate and glycerol monolaurate, and
- the amphoteric surfactant is one or more selected from the group consisting of natural lecithin, synthetic lecithin and phospholipids:
- wherein an amount of the osmotic pressure regulator is 0.7%~1.0% based on the total mass of the suspension;
- and
- wherein an amount of the metal complexing agent is 0.01%~0.05% based on the total mass of the suspension.
Dependencies are inferred from the claim text.