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US 12,758,542 B2Granted
Methods for treating pancreatic ductal adenocarcinoma
AssigneeHealth Research, Inc.
InventorsAbdulrahman A. Alahmari, Michael Feigin
Life of this patent
Estimating the term…
Abstract
Provided are methods for treating individuals suspected of having or having Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) associated cancer via administration of a CPSF3 inhibitor. Such cancers include pancreatic ductal adenocarcinoma (PDAC). The CPSF3 inhibitor may further attenuate PDAC cell proliferation and colony formation. The CPSF3 inhibitor may be JTE-607, which has the following structure:
Claims3
A method for treating an individual for pancreatic ductal adenocarcinoma (PDAC) consisting of administering to the individual
- or a pharmaceutically acceptable salt thereof, and afatinib or Osimertinib, and wherein the JTE-607 and the afatinib or Osimertinib synergistically inhibits growth of the PDAC.
Dependencies are inferred from the claim text.