US 12,758,528 B2 · Compounds having Pseudomonas anti-biofilm properties

Abstract

The present invention relates to c-di-GMP lowering chemical compounds having anti-biofilm properties. In particular, the present invention relates to anti-biofilm compounds or salts or tautomers thereof for use in treatment and/or prevention of bacterial biofilm infection in human subjects caused by biofilm-forming bacteria of the genus Pseudomonas, in particular Pseudomonas spp. including P. aeruginosa. Methods of treating such infections in human subjects are contemplated as well. The present inventions further relates to the use of an anti-biofilm compound or a salt or tautomer thereof for dispersing biofilms in industrial water systems.

Claims11

Dependent claims

A method of inhibiting or treating a Pseudomonas bacterial biofilm infection in a subject comprising:

administering a compound according to chemical formula (1) to a subject that has a Pseudomonas bacterial biofilm infection:
wherein R1, R2, and R3 are hydrogen, hydroxy, or fluoro, and pharmaceutically acceptable salts of the primary or secondary amino groups, wherein the primary or secondary amino groups are protonated and the resulting positive charge is countered by an anion amine group.

Dependencies are inferred from the claim text.

Facts

Application

18/042,755Filed 27 Aug 2021

Priority

EP 2019305027 Aug 2020

Published

US 2023/0321043 A112 Oct 2023

Granted

13 Oct 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 31/415
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: 1,2-Diazoles
A01N 43/56
Having rings with two nitrogen atoms as the only ring hetero atoms: 1,2-Diazoles; Hydrogenated 1,2-diazoles
A01N 43/80
Having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms: five-membered rings with one nitrogen atom and either one oxygen…
A01P 1/00
Disinfectants

Compounds having Pseudomonas anti-biofilm properties

Life of this patent

Compounds having Pseudomonas anti-biofilm properties

Life of this patent

Abstract

Claims11