Methods for treatment of damaged biliary duct
AssigneeMor Research Applications Ltd.
InventorOrith Waisbourd-Zinman
Life of this patent
Estimating the term…
Abstract
Methods of treating damaged bile ducts by way of elevating glutathione (GSH) levels, restoring normal GSH levels, and/or maintaining normal GSH levels in the biliary ducts are disclosed. A disclosed method comprises local treatment of damaged biliary ducts, e.g., by directly delivering to the bile ducts lumen of at least one active agent that promotes increasing of GSH production or inhibiting of GSH degradation in the biliary epithelial cells.
Claims20
A method of treating a damaged bile duct in a subject having a damaged bile duct, the method comprising administering to the subject a pharmaceutically effective amount of one or more active agents which promote elevation of glutathione (GSH) levels or restoration of normal GSH levels, and/or maintenance of normal GSH levels in the biliary duct, wherein elevation, restoration, or maintenance of GSH levels occurs in biliary epithelial cells (BECs), thereby treating the damaged bile duct in the subject, wherein the damaged bile duct is other than a bile duct having damage due to ligation.
A method for treatment of biliary duct damage in a subject having a damaged biliary duct, the method comprising locally administering to the damaged biliary duct of the subject a pharmaceutically effective amount of one or more active agents which promote at least one of:
- elevation of glutathione (GSH) levels, restoration of normal GSH levels, or maintenance of normal GSH levels in the biliary ducts, thereby treating the damaged biliary duct.
A method of treating a damaged bile duct in a subject having a damaged bile duct, the method comprising administering to the subject a pharmaceutically effective amount of one or more active agents which promote elevation of glutathione (GSH) levels or restoration of normal GSH levels, and/or maintenance of normal GSH levels in the biliary duct, wherein elevation, restoration, or maintenance of GSH levels occurs in biliary epithelial cells (BECs), thereby treating the damaged bile duct in the subject, wherein the damaged bile duct is a bile duct whose damage is caused by a cholangiopathy and/or cholestasis.
Dependencies are inferred from the claim text.