Pharmaceutical composition for treating onychomycosis and relieving ingrown toenail pain

A method of treating onychomycosis or relieving ingrown toenail pain while enhancing nail growth in a subject, comprising:

• topically administering to a fingernail or toenail of the subject a pharmaceutical composition in the form of a hydrogel patch,
• wherein the hydrogel patch comprises:
• a release layer;
• a hydrogel layer disposed on the release layer;
• and
• a backing layer laminated on the hydrogel layer, the backing layer comprising a non-woven fabric coated with polyurethane,
• wherein the hydrogel layer has a viscosity of 100,000 to 2,000,000 cps at 25° C., and comprises, based on a total weight of the hydrogel layer;
• 10 to 20 wt % of urea;
• 1 to 2.3 wt % of fumaric acid;
• 0.1 wt % of biotin;
• 9 to 15 wt % of 1,3-butylene glycol;
• 5 to 10 wt % of a gel-forming polymer, wherein the gel-forming polymer comprises polyacrylic acid, a copolymer of acrylic acid and sodium acrylate, or a mixture of polyacrylic acid and the copolymer of acrylic acid and sodium acrylate;
• 0.1 to 0.5 wt % of a crosslinking agent;
• and
• 45 to 60 wt % of water,
• wherein the pharmaceutical composition has keratolytic and moisture-retention abilities to provide a hydrated environment for fingernails, toenails, and surrounding tissues.