Capsaicin derivatives in the treatment of idiopathic pulmonary fibrosis

A method for the treatment of idiopathic pulmonary fibroses (IPF) of a subject, the method comprising the step of administering an effective amount of a compound of formula II, or a pharmaceutically acceptable salt or solvate thereof,

• wherein
• X is selected from oxygen and sulphur;
• Ar denotes an aryl group optionally containing one or more nitrogen, oxygen, or sulphur atoms, and optionally substituted in any one or more positions with one or more identical or different substituents selected from the group of nitro, trifluoromethyl, C1-C6 straight chain and branched alkoxy, C1-C6 straight chain and branched alkyl;
• R′ is selected from the group of hydrogen, C1-C6 straight chain or branched alkyl;
• and
• R is selected from the group of hydrogen;
• C1-C6 straight chain and branched alkyl, alkenyl, and alkynyl;
• C3-C6 cycloalkyl;
• acyl groups COR1 wherein R1 is selected from the group comprising or consisting of C1-C6 straight chain and branched alkyl, alkenyl, and alkynyl, C3-C6 cycloalkyl and phenyl.