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US 12,758,501 B2Granted
Pharmaceutical compositions having high drug loadings of medium chain triglycerides and methods related thereto
AssigneeCerecin Inc.
InventorsAaron M. Badenoch, Taryn Boivin, Devon B. DuBose, Samuel T. Henderson, Christi Lynn Hostetler, David K. Lyon, Craig A Sather, Matthew J. Shaffer
Life of this patent
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Abstract
This invention relates to high drug load compositions of medium chain triglycerides (MCT), and to methods for treatment with such compositions at amounts effective to elevate ketone body concentrations so as to treat conditions associated with reduced neuronal metabolism, for example Alzheimer's disease.
Claims9
A dried pharmaceutical powder composition comprising:
- an active agent consisting of caprylic triglyceride having a purity of at least 95% and at least two surfactants independently selected from the group consisting of polyoxyl hydrogenated castor oil, polyoxyl stearate, polyoxyl hydroxystearate, lecithin, phosphatidylcholine, and combinations thereof;
- and a film forming polymer selected from polyvinylpyrrolidone (PVP) or polyvinylpyrrolidone-vinyl acetate copolymer (PVP-VA),
- wherein the caprylic triglyceride is present in an amount of about 40% to about 65% by weight of the total composition,
- wherein the caprylic triglyceride is encapsulated,
- wherein the particles of the dried pharmaceutical powder are free flowing,
- and wherein the dried pharmaceutical powder composition forms a stable emulsion in an aqueous environment for at least about 4 hours at ambient conditions.
3 more elements
Dependencies are inferred from the claim text.