# US 12,758,500 B2 · Pharmaceutical composition for improving respiratory damage and use for manufacturing pharmaceutical composition for improving respiratory damage > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,758,500 B2 - Document ID: US12758500B2 - Status: Granted - Kind: B2 - Application number: 18/591,896 - Filed: 2024-02-29 - Published: 2024-08-01 - Granted: 2026-10-13 - Earliest claimed: 2021-06-01 - Applicants: Ming-Chien Hung - Inventors: Ming-Chien Hung - Web page: https://patentgrep.com/patent/US12758500B2 ## CPC - A61K 9/1611: {Inorganic compounds} - A61K 9/0073: {Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy; (nasal sprays A61K9/0043; inhalation of vapours of volatile or heated drugs, e.g. essential oils or nicotine, A61K9/007; devices A61M)} - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 11/00: Drugs for disorders of the respiratory system - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention provides a pharmaceutical composition for improving respiratory damage. The pharmaceutical composition includes an adsorbent medicament and a water-containing carrier, wherein said adsorbent medicament comprises a carbon material, a molecular sieve or a positively and negatively charged compound. The present invention also provides use for manufacturing pharmaceutical composition for improving respiratory damage. ## Claims ### Claim 1 A pharmaceutical composition for improving respiratory damage, comprising an adsorbent medicament, wherein said adsorbent medicament comprises a carbon material and a water-containing carrier, wherein said carbon material is selected from a group consisting of activated carbon, activated carbon fiber, activated carbon ball, columnar activated carbon, activated carbon powder, and a combination thereof, wherein said carbon material has a mean particle diameter ranging from 0.1 to 500 μm, wherein said carbon material has a specific surface area (BET) ranging from 300 to 3000 m2/g, wherein said carbon material has a micropore diameter ranging from 1 to 500 nm, wherein said water-containing carrier is selected from the group consisting of normal saline, buffers, isotonic saline solution, and a combination thereof, said adsorbent medicament mixed with said water-containing carrier is formulated as a suspension at a concentration ranging from 0.001 to 1 wt %, wherein the adsorbent carbon material is configured for administration into a respiratory system by inhalation or instillation to be delivered to a respiratory tract, lungs, or alveoli, to adsorb toxic substances, bacteria, viruses, proinflammatory cytokines, chemokines, or cytokines in the respiratory system, and wherein the pharmaceutical composition improves respiratory system damage. ### Claim 2 (depends on 1) The pharmaceutical composition according to claim 1, wherein said carbon material has a volume in pores ranging from 0.1 to 3.0 ml/g. ### Claim 3 (depends on 1) The pharmaceutical composition according to claim 1, wherein said pharmaceutical composition further comprises at least one of an adjuvant, an excipient, or a propellant. ### Claim 4 (depends on 1) The pharmaceutical composition according to claim 1, further comprising a medicine selected from a group consisting of an antibacterial medicine, an antiviral medicine, an anticoagulant medicine, a thrombolytic medicine, an alpha-blocker, a 5a-Reductase inhibitor, a nasal decongestant, an antitussive, an expectorant, a mucolytic, a bronchodilator, an antibiotic, an antifungal medicine, an antiasthmatic medicine, an anti-inflammatory medicine, an antioxidant, a Chinese medicine extract, an antibody, and a vaccine. ### Claim 5 (depends on 1) The pharmaceutical composition according to claim 1, wherein said carbon material further comprises at least one of oxygen functional groups, hydroxyl functional groups, hydroxyl, carboxylic acid, aldehyde groups, and carbonic acid. ### Claim 6 (depends on 1) The pharmaceutical composition according to claim 1, further comprising an element selected from a group consisting of metal ions, magnetic materials, cation compounds, anion compounds, or halogen ions, and a combination thereof. ### Claim 7 A method for improving respiratory damage, the method comprising: (a) providing a pharmaceutical composition comprising an adsorbent medicament, wherein said adsorbent medicament comprises a carbon material and a water-containing carrier; (b) administering said pharmaceutical composition into a respiratory system of the patient by inhalation or instillation to deliver the carbon material to a respiratory tract, lungs, or alveoli, to adsorb toxic substances, bacteria, viruses, proinflammatory cytokines, chemokines, or cytokines in the respiratory system; and (c) removing the pharmaceutical composition out of the lungs of the patient, wherein said carbon material is selected from the group consisting of activated carbon, activated carbon fiber, activated carbon ball, columnar activated carbon, activated carbon powder, and a combination thereof, wherein said carbon material has a mean particle diameter ranging from 0.1 to 500 μm, a specific surface area (BET) ranging from 300 to 3000 m2/g, and a micropore diameter ranging from 1 to 500 nm, wherein said water-containing carrier is selected from the group consisting of normal saline, buffers, isotonic saline solution, and a combination thereof, and wherein said adsorbent medicament mixed with said water-containing carrier is formulated as a suspension at a concentration ranging from 0.001 to 1 wt %.