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US 12,758,495 B2Granted
Compositions and methods for treating pulmonary edema or lung inflammation
AssigneeRegents of the University of Minnesota
InventorsDavid H. Ingbar, Timothy P. Rich, Robert J. Schumacher, Jianxun Lei, Maneesh Bhargava
Life of this patent
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Abstract
A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes a salt of triiodothyronine and a pharmaceutically acceptable buffer, adjusted to a pH of 5.5-8.5. The composition can be administered prophylactically or therapeutically to a subject to treat lung inflammation or pulmonary edema.
Claims25
A pharmaceutical composition comprising:
- a salt of triiodothyronine in an amount effective to provide a lung-delivered dose of from 100 ng to 2 mg;
- an inhibitor of deiodinase-3 (D3);
- and
- a pharmaceutically acceptable buffer;
- wherein the composition delivered to the pulmonary tract has a pH from 5.5 to 8.5 and a maximum volume of no more than 0.30 ml per 1.67 g wet lung weight per dose.
2 more elements
Dependencies are inferred from the claim text.