# US 12,758,489 B2 · Bio-inspired tissue-adhesive hydrogel patch for preventing or treating cartilage or bone disease

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- Number: US 12,758,489 B2
- Document ID: US12758489B2
- Status: Granted
- Kind: B2
- Application number: 18/176,890
- Filed: 2023-03-01
- Published: 2023-06-29
- Granted: 2026-10-13
- Earliest claimed: 2020-09-01
- Assignees: Cellartgen Inc.
- Applicants: Cellartgen Inc.
- Inventors: Seung Woo Cho; Soo Jeong Choi; Eun Je Jeon; Jong Seung Lee
- Web page: https://patentgrep.com/patent/US12758489B2

## CPC

- A61K 9/0024: {Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 31/573: substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
- A61K 38/1875: {Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor}
- A61K 47/02: Inorganic compounds
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 19/08: for bone diseases, e.g. rachitism, Paget's disease
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present disclosure relates to a hydrogel patch for preventing or treating cartilage or bone diseases, including: a hydrogel patch containing a biocompatible polymer functionalized with a phenol group; and a drug for treating cartilage or bone diseases loaded in the hydrogel patch.

## Claims

### Claim 1

A hydrogel patch for preventing or treating cartilage or bone diseases, comprising: a biocompatible polymer functionalized with a phenol group; a drug for treating cartilage or bone diseases loaded in the hydrogel patch; and inorganic mineral particles, wherein the biocompatible polymer is pyrogallol-functionalized hyaluronic acid with 5-hydroxydopamine (HA-PG) and the inorganic mineral particles are hydroxyapatite (HAP) or whitlockite (WKT).

### Claim 2 (depends on 1)

The hydrogel patch for preventing or treating cartilage or bone diseases of claim 1,
wherein the hydrogel patch has
i) a thickness of from 0.05 mm to 10.0 mm,
ii) a storage modulus G′ of from 1×103 Pa to 1×106 Pa in a frequency range of from 0.1 Hz to 10 Hz,
iii) a friction factor of from 0.2 to 0.4 as measured at a speed of 0.01 m/s under a normal force of 5 N, and
iv) an adhesive strength of from 10 kPa to 20 kPa.

### Claim 3 (depends on 1)

The hydrogel patch for preventing or treating cartilage or bone diseases of claim 1,
wherein the inorganic mineral particles include one or more inorganic ions selected from the group consisting of calcium, magnesium and phosphorus.

### Claim 4 (depends on 3)

The hydrogel patch for preventing or treating cartilage or bone diseases of claim 3,
wherein the inorganic ions interact with the phenol group to form a complex compound through coordination bonding.

### Claim 5 (depends on 3)

The hydrogel patch for preventing or treating cartilage or bone diseases of claim 3,
wherein the inorganic ions make ionic interactions with the drug.

### Claim 6 (depends on 1)

The hydrogel patch for preventing or treating cartilage or bone diseases of claim 1,
wherein the drug contains:
an anti-inflammatory agent selected from the group consisting of dexamethasone, cortisone, prednisolone, hydrocortisone, triamcinolone, methylprednisolone, prednisone and betamethasone; or
a bone morphogenic protein selected from the group consisting of BMP-2 (BMP-2a), BMP-3 (osteogenin), BMP-4 (BMP-2b), BMP-6 (human homologue of the murine, Vgr-1), BMP-7 (osteogenic protein-1) and BMP-9 (growth differentiation factor 2).

### Claim 7 (depends on 1)

The hydrogel patch for preventing or treating cartilage or bone diseases of claim 1,
wherein the cartilage disease is selected from the group consisting of inflammatory arthritis, degenerative arthritis, osteochondromatosis, distortion, bursitis, menstruation, meniscal tear, meniscus cyst, collateral ligament rupture, anterior cruciate ligament injury, posterior cruciate ligament injury, intraarticular vitreous, exfoliation osteochondritis, plica syndrome, genu varum, knock-knee and snapping knee, and
the bone disease is selected from the group consisting of growth retardation, osteopenia, osteopsathyrosis, osteonecrosis, fracture, osteoporosis due to excessive bone resorption by osteoclasts, osteogenesis imperfecta, bone damage, joint damage due to trauma, osteomalacia, rickets, fibrous osteitis, aplastic bone disease, metabolic bone disease, renal osteodystrophy, periodontal disease, Paget disease and metastatic bone cancers.