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US 12,758,487 B2Granted
Methods for dose initiation of aripiprazole treatments
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsMatthew Harlin, Xiaofeng Wang, Yanlin Wang, Arash Raoufinia
Life of this patent
Estimating the term…
Abstract
The present disclosure is directed to a method of dose initiation for an aripiprazole treatment to a patient in need thereof; the patient is administered two, separate 100 to 500 mg injections of an aripiprazole intramuscular (IM) depot formulation at separate gluteal and/or deltoid injection sites, and a single dose of oral aripiprazole. The administration occurs on a first day of the treatment.
Claims10
A method of administering an aripiprazole treatment to a patient in need thereof comprising:
- administering a one-day dose initiation consisting of two, separate injections of an aripiprazole intramuscular (IM) depot formulation, wherein each injection comprises 300 mg or 400 mg of aripiprazole, to the patient at separate injection sites chosen from gluteal sites, deltoid sites, and a gluteal site and a deltoid site, and a single dose of oral aripiprazole ranging from about 10 mg to about 30 mg of aripiprazole in a tablet, wherein the step of administering the two separate injections and the single oral dose occurs on a first day of the treatment,
- wherein the patient has schizophrenia, and
- wherein the aripiprazole intramuscular (IM) depot formulation comprises aripiprazole monohydrate.
Dependencies are inferred from the claim text.