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US 12,758,484 B2Granted
Topical formulations of recombinant collagens
AssigneeGeltor, Inc.
InventorsLaura Brightman, Alexander Lorestani, Nikolay Ouzounov
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Abstract
Methods of improving firmness, elasticity, brightness, hydration, tactile texture or visual texture of skin are described herein. In some aspects, the methods comprise topically applying non-naturally occurring truncated collagen molecules to skin.
Claims12
A non-naturally occurring polypeptide produced in a microbial host cell, the non-naturally occurring polypeptide comprising an amino acid sequence having at least about 80% sequence identity to a truncate of SEQ ID NO:
- 31, wherein:
- i) the truncate of SEQ ID NO:
- 31 has a truncation at both the N-terminal end and the C-terminal end,
- ii) the truncate of SEQ ID NO:
- 31 has a total truncation of 500 amino acids to 770 amino acids,
- iii) the non-naturally occurring polypeptide comprises the amino acid sequence of SEQ ID NO:
- 16, and
- iv) the non-naturally occurring polypeptide lacks glycine-proline-hydroxyproline triplets and does not form a triple helix structure of natural collagen.
5 more elements
Dependencies are inferred from the claim text.