# US 12,758,477 B2 · Sunscreen compositions

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- Number: US 12,758,477 B2
- Document ID: US12758477B2
- Status: Granted
- Kind: B2
- Application number: 17/524,222
- Filed: 2021-11-11
- Published: 2022-05-26
- Granted: 2026-10-13
- Earliest claimed: 2020-05-13
- Assignees: Curie Co. Inc.
- Applicants: Curie Co. Inc.
- Inventors: Erika M. Milczek; William Shindel; Zsolt Szabados
- Web page: https://patentgrep.com/patent/US12758477B2

## CPC

- A61K 8/40: containing nitrogen (quinones containing nitrogen A61K8/355)
- A61K 8/41: Amines
- A61K 8/445: {aromatic, i.e. the carboxylic acid directly linked to the aromatic ring}
- A61K 8/466: {containing sulfonic acid derivatives; Salts}
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/66: Enzymes
- A61K 8/891: saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- C12N 9/0022: {with oxygen as acceptor (1.4.3)}
- C12N 9/1022: {transferring aldehyde or ketonic groups (2.2)}
- C12Y 203/02013: Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
- A61K 2800/26: Optical properties
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12Y: ENZYMES

## Abstract

Sunscreen compositions and sunscreen active ingredients are disclosed herein which comprise at least one ketone-containing UV filter and at least one primary or secondary amine wherein at least one ketone-containing UV filter and at least one primary or secondary amine react to form an imine analog of the ketone-containing UV filter wherein the imine analog has at least one property selected from the group consisting of a) is capable of extending UV protection into a visible region equal to or greater than 400 nm, b) is water resistant, and/or c) prevents or decreases skin penetration. This imine analog may be further modified to provide a substrate capable of reacting with transglutaminase or any variant thereof and/or a lysyl oxidase to bind the sunscreen composition or sunscreen active ingredient to a target of interest. Also disclosed are cosmetic or pharmaceutical preparations comprising any of the sunscreen compositions or sunscreen ingredients along with a cosmetically or pharmaceutically acceptable carrier.

## Claims

### Claim 1

A sunscreen composition comprising an imine analog of a ketone-containing UV filter, wherein the imine analog is selected from:

### Claim 2 (depends on 1)

The sunscreen composition of claim 1, further comprising a transglutaminase or variant thereof and/or a lysyl oxidase.

### Claim 3

A sunscreen active ingredient, wherein the sunscreen active ingredient is an imine analog of a ketone-containing UV filter selected from the group consisting of

### Claim 4 (depends on 3)

A cosmetic or pharmaceutical preparation comprising the sunscreen active ingredient of claim 3 and a cosmetically or pharmaceutically acceptable carrier.