# US 12,758,472 B2 · Formulation for treatment of melasma, hyperpigmentation, and dark spots

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- Number: US 12,758,472 B2
- Document ID: US12758472B2
- Status: Granted
- Kind: B2
- Application number: 18/445,907
- Filed: 2024-03-19
- Published: 2025-09-25
- Granted: 2026-10-13
- Earliest claimed: 2024-03-19
- Applicants: Julia Kleczkowski; Ginger King
- Inventors: Julia Kleczkowski; Ginger King
- Web page: https://patentgrep.com/patent/US12758472B2

## CPC

- A61K 8/0204: {Specific forms not provided for by any of groups A61K8/0208 - A61K8/14}
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61K 2800/524: Preservatives
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A formulation for treatment of hyperpigmentation and melasma, is provided, comprising five actives consists of: a blend of caprylic or capric triglycerides, hexylresorcinol, and ethyl linoleate; hexylresorcinol; a blend of tetrapeptide and glycerin; a blend of Rumex occidentalis extract, ascorbic acid and glycerin; and a blend of Humulus lupulus extract, caprylic or capric triglycerides.

## Claims

### Claim 1

A formulation consisting of caprylic triglycerides, capric triglycerides, hexylresorcinol, ethyl linoleate, tetrapeptide, glycerin, Rumex occidentalis extract, ascorbic acid, Humulus lupulus extract, at least one preservative, at least one moisturizing agent, at least one serum forming agent, at least one penetration enhancer, a hydrating agent, an anti-microbial agent, and a fragrance,
said at least one preservative is selected from the group consisting of glyceryl caprylate, glyceryl undecylenate and mixtures and combinations thereof, said at least one moisturizing agent is squalane, said at least one serum forming agent is polyacrylate crosspolymer, said at least one penetration enhancer is pentylene glycol, and said hydrating agent is water.

### Claim 2

A formulation comprising a therapeutic amount of five actives, said five actives consists of: a blend of caprylic or capric triglycerides, hexylresorcinol, and ethyl linoleate; hexylresorcinol; a blend of tetrapeptide and glycerin; a blend of Rumex occidentalis extract, ascorbic acid and glycerin; and a blend of Humulus lupulus extract, caprylic or capric triglycerides.

### Claim 3 (depends on 2)

The formulation of claim 2 wherein said actives are incorporated into a serum.

### Claim 4 (depends on 2)

The formulation of claim 2 wherein each of the five actives are in the amount from about 0.5 to about 10% by weight of said formulation.

### Claim 5 (depends on 2)

The formulation of claim 2 further comprises a preservative in the amount from about 0.1 to about 5.0% by weight of said formulation.

### Claim 6 (depends on 2)

The formulation of claim 2 further comprises a moisturizing agent in the amount from about 1.0 to about 10.0% by weight of said formulation.

### Claim 7 (depends on 2)

The formulation of claim 2 further comprises a serum forming agent in the amount from about 0.1 to about 5.0% by weight of said formulation.

### Claim 8 (depends on 2)

The formulation of claim 2 further comprises a penetration enhancer in the amount from about 1.0 to about 20.0% by weight of said formulation.

### Claim 9 (depends on 2)

The formulation of claim 2 further comprises a hydrating agent in the amount from about 10.0 to about 65.0% by weight of said formulation.

### Claim 10 (depends on 2)

The formulation of claim 2 further comprises an additive, said additive being selected from the group consisting of a preservative, a moisturizing agent, a serum forming agent, a penetration enhancer, a hydrating agent, a fragrance, a colorant, and mixture and combinations thereof.