# US 12,758,238 B2 · Thrombus removal systems and associated methods

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- Number: US 12,758,238 B2
- Document ID: US12758238B2
- Status: Granted
- Kind: B2
- Application number: 18/864,484
- Filed: 2023-05-10
- Published: 2025-10-02
- Granted: 2026-10-13
- Earliest claimed: 2022-05-10
- Assignees: Shifamed Holdings, LLC
- Applicants: Shifamed Holdings, LLC
- Inventors: Aadel Al-Jadda; Amr Salahieh; Oscar Williams; Paul Gunning; Nicholas Lyford; Tom Saul
- Web page: https://patentgrep.com/patent/US12758238B2

## CPC

- A61B 17/22: Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B 17/00234: {for minimally invasive surgery (A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence)}
- A61B 2017/00238: {Type of minimally invasive operation (A61B2017/00805 takes precedence)}
- A61B 2017/00305: {Constructional details of the flexible means}
- A61B 2017/22079: {with suction of debris}
- A61B 2017/22084: {stone- or thrombus-dissolving}
- A61B 2217/005: with suction drainage system
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

The present technology relates to systems and methods for removing a thrombus from a blood vessel of a patient. In some embodiments, the present technology is directed to systems including an elongated catheter having a distal portion configured to be positioned within the blood vessel of the patient, a proximal portion configured to be external to the patient, and a lumen extending therebetween. The system can also include a fluid delivery mechanism coupled with a fluid lumen and configured to apply fluid, including a particularized media, to at least partially fragment the thrombus.

## Claims

### Claim 1

A thrombectomy method, comprising:
delivering a distal portion of an elongate catheter into proximity with a thrombus in a blood vessel;
engaging the distal portion with the thrombus; and
directing a particulate media towards the thrombus along at least two intersecting paths.

### Claim 2 (depends on 1)

The method of claim 1, further comprising aspirating the thrombus out of the blood vessel.

### Claim 3 (depends on 1)

The method of claim 1, wherein directing the particulate media towards the thrombus further comprises combining the particulate media with a pressurized fluid.

### Claim 4 (depends on 1)

The method of claim 1, further comprising directing a fluid stream towards the thrombus.

### Claim 5 (depends on 4)

The method of claim 4, wherein the fluid stream is directed towards the thrombus with one or more fluid stream apertures and the particulate media is directed towards the thrombus with one or more particulate media apertures.

### Claim 6 (depends on 4)

The method of claim 4, wherein the fluid stream is carried within one or more fluid lumens in the elongate catheter and the particulate media is carried within one or more particulate media lumens in the elongate catheter.

### Claim 7 (depends on 1)

The method of claim 1, wherein the particulate media is an abrasive mixture.

### Claim 8 (depends on 1)

The method of claim 1, wherein the particulate media comprises a salt.

### Claim 9 (depends on 1)

The method of claim 1, wherein the particulate media comprises a sugar.

### Claim 10 (depends on 1)

The method of claim 1, wherein the particulate media comprises a contrast media.

### Claim 11 (depends on 1)

The method of claim 1, wherein the particulate media comprises lactated ringers.

### Claim 12 (depends on 1)

The method of claim 1, wherein the particulate media comprises microparticles.

### Claim 13 (depends on 1)

The method of claim 1, wherein the particulate media comprises microbeads.

### Claim 14 (depends on 1)

The method of claim 1, wherein the particulate media includes a coating configured to reduce dissolution of the particulate media within the body.

### Claim 15 (depends on 14)

The method of claim 14, wherein the coating is a lipid coating.

### Claim 16 (depends on 1)

The method of claim 1, wherein directing the particulate media further comprises:
delivering a fluid to a mixing chamber;
delivering the particulate media to the mixing chamber; and
fluidizing the particulate media in the mixing chamber with the fluid.

### Claim 17 (depends on 1)

The method of claim 1, wherein delivering the distal portion further comprises delivering the distal portion into the blood vessel in a low-profile configuration, and wherein the method further comprises expanding the distal portion into a deployed configuration.

### Claim 18 (depends on 1)

The method of claim 1, wherein the blood vessel comprises a pulmonary artery.

### Claim 19

A thrombectomy method, comprising:
delivering a distal portion of an elongate catheter into proximity with a thrombus in a blood vessel;
engaging the distal portion with the thrombus;
delivering a fluid to a mixing chamber;
delivering a particulate media to the mixing chamber;
fluidizing the particulate media in the mixing chamber with the fluid; and
directing the fluidized particulate media towards the thrombus.