Automated systems and methods for separating compounds
AssigneeDH Technologies Development Pte. Ltd.
InventorsLeigh Bedford, Bradley B. Schneider
Life of this patent
Estimating the term…
Abstract
A gas introduction system for a differential mobility spectrometer (DMS) includes a manifold including a gas inlet and a gas outlet. A mixing channel fluidically couples the gas inlet to the gas outlet. A plurality of modifier liquid supply inlets is coupled to the mixing channel and a plurality of selectively operable valves. One of the plurality of selectively operable valves is coupled to one of the plurality of modifier liquid supply inlets. A control system is in communication with each of the plurality of the selectively operable valves. The control system is configured to actuate each of the plurality of selectively operable valves.
Claims11
A gas introduction system for a differential mobility spectrometer (DMS), the system comprising:
- a manifold comprising:
- a gas inlet;
- a gas outlet;
- a mixing channel fluidically coupling the gas inlet to the gas outlet;
- a sensor disposed in the mixing channel;
- a plurality of modifier liquid supply inlets coupled to the mixing channel;
- and
- a plurality of selectively operable valves, wherein one of the plurality of selectively operable valves is coupled to one of the plurality of modifier liquid supply inlets;
- and
- a control system in communication with each of the plurality of the selectively operable valves, wherein the control system is configured to actuate each of the plurality of selectively operable valves.
A system for processing a sample, the system comprising:
- a differential mobility spectrometer (DMS) comprising an inlet;
- a manifold coupled to the DMS, wherein the manifold comprises a mixing channel;
- a gas source fluidically coupled to the mixing channel;
- a plurality of modifier sources fluidically coupled to the mixing channel;
- a processor;
- and
- memory storing instructions that, when executed by the processor, cause the system to perform operations comprising:
- introducing the sample of the DMS while introducing a gas flow from the gas source to the mixing channel;
- selecting, by the DMS, a first subset of ions in the sample, based at least in part on the introduced sample and the introduced gas flow;
- while introducing the sample to the DMS and introducing the gas flow to the mixing channel of the manifold, sequentially introducing to the mixing channel a plurality of modifiers from each of the plurality of modifier sources;
- selecting, by the DMS, a plurality of different subsets of ions in the sample, based at least in part on the introduced sample, the introduced gas flow, and the plurality of modifiers;
- comparing the first subset of ions to at least one of the different subsets of ions;
- and
- based at least in part on the comparison, selecting one of (a) a curtain gas and (b) at least one of the plurality of modifiers.
Dependencies are inferred from the claim text.