Method for determining a measure of a rate of decay and mass spectrometry system
AssigneeThermo Fisher Scientific (Bremen) GmbH
InventorsKyle Fort, Alexander Makarov, Konstantin Ayzikov
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Abstract
Methods and systems for determining a measure of a rate of decay of an ion sample. Specifically, the present disclosure provides methods and apparatus for determining decay constants and cross-section measurements in parallel to mass measurement and decay time correction. The disclosure particularly relates to methods and apparatus for performing Fourier transform mass spectrometry (FTMS).
Claims20
A mass spectrometry system comprising:
- a mass analyser configured to perform mass analysis with image current detection;
- a processor;
- and
- memory storing instructions that, when executed on a processor, cause the performance of a method for determining a measure of a rate of decay of an ion sample undergoing mass analysis in the mass analyser with image current detection, the method comprising:
- receiving a detection signal for the ion sample from a transient detection of the ion sample obtained using the mass analyser, the detection signal for the ion sample having a rate of decay over time;
- and
- determining the measure of the rate of decay of the ion sample based on an extrapolated resolution for the ion sample, the extrapolated resolution being an expected resolution of the detection signal in conditions in which the rate of decay over time of the detection signal for the ion sample is dominated by collisional effects.
Non-transitory computer-readable media storing instructions that, when executed on a processor, cause the performance of a method for determining a measure of a rate of decay of an ion sample undergoing mass analysis in a mass analyser with image current detection, the method comprising:
- directing the mass analyser to perform the mass analysis of the ion sample with image current detection;
- receiving a detection signal for the ion sample from a transient detection of the ion sample obtained using the mass analyser, the detection signal for the ion sample having a rate of decay over time;
- and
- determining the measure of the rate of decay of the ion sample based on an extrapolated resolution for the ion sample, the extrapolated resolution being an expected resolution of the detection signal in conditions in which the rate of decay over time of the detection signal for the ion sample is dominated by collisional effects.
Dependencies are inferred from the claim text.