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US 12,754,193 B2Granted
Molecular profiling of tumors
AssigneeCaris MPI, Inc.
InventorsDaniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski
Life of this patent
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Abstract
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.
Claims23
A method for conducting molecular profiling using a computer system, the method comprising:
- storing a set of applications in a storage medium of the computer system, wherein each of the set of applications is configured to use a specific subset of data to generate output data;
- for each of a plurality of patients that have cancerous cells and that will receive cancer treatment:
- (a) obtaining clinical data by the computer system, wherein the clinical data includes cancer state information, and any prior treatment regimens and/or treatment efficacy information;
- (b) storing, by the computer system, the clinical data in a first database of the computer system;
- (c) for each patient, using at least one laboratory assay to generate molecular profiling data for the cancerous cells;
- (d) storing, by the computer system, the molecular profiling data in the first database;
- (e) transforming, by the computer system, at least a subset of data in the first database to generate structured data including the clinical data and the molecular profiling data, wherein the structured data is configured for searching using the computer system;
- (f) storing, by the computer system, the structured data in a second database of the computer system;
- (g) for each application of the set of applications:
- (i) selecting, by the computer system, the application specific subset of data from the second database;
- and
- (ii) storing, in a third database of the computer system, the application specific subset of data in a structure configured for accessing by the application executing on the computer system.
9 more elements
A system for conducting molecular profiling, the system comprising:
- a host server;
- a user interface for accessing the host server to access and input data;
- one or more processors for processing the inputted data;
- a first database, a second database, and a third database;
- and
- a memory coupled to the one or more processors for storing the processed data and instructions for:
- storing a set of applications in the memory, wherein each of the set of applications is configured to use a specific subset of data to generate output data;
- for each of a plurality of patients that have cancerous cells and that will receive cancer treatment:
- (a) obtaining clinical data, wherein the clinical data includes cancer state information, and any prior treatment regimens and/or treatment efficacy information;
- (b) storing the clinical data in the first database;
- (c) for each patient, receiving molecular profiling data for the cancerous cells, the molecular profiling data generated using at least one laboratory assay;
- (d) storing the molecular profiling data in the first database;
- (e) transforming at least a subset of data in the first database to generate structured data including the clinical data and the molecular profiling data, wherein the structured data is configured for searching using the system;
- (f) storing the structured data in the second database;
- (g) for each application of the set of applications:
- (i) selecting the application specific subset of data from the second database;
- and
- (ii) storing, in the third database, the application specific subset of data in a structure configured for accessing by the application.
15 more elements
A non-transitory computer readable medium storing instructions that, when executed by a computer system, cause the computer system to perform:
- storing a set of applications in a storage medium of the computer system, wherein each of the set of applications is configured to use a specific subset of data to generate output data;
- for each of a plurality of patients that have cancerous cells and that will receive cancer treatment:
- (a) obtaining clinical data, wherein the clinical data includes cancer state information, and any prior treatment regimens and/or treatment efficacy information;
- (b) storing the clinical data in a first database of the computer system;
- (c) for each patient, receiving molecular profiling data for the cancerous cells, the molecular profiling data generated using at least one laboratory assay;
- (d) storing the molecular profiling data in the first database;
- (e) transforming at least a subset of data in the first database to generate structured data including the clinical data and the molecular profiling data, wherein the structured data is configured for searching using the computer system;
- (f) storing the structured data in a second database of the computer system;
- (g) for each application of the set of applications:
- (i) selecting the application specific subset of data from the second database;
- and
- (ii) storing, in a third database, the application specific subset of data in a structure configured for accessing by the application executing on the computer system.
9 more elements
Dependencies are inferred from the claim text.