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AssigneeInstitut de Cardiologie de Montreal
InventorsJohn D. Rioux, Christine Des Rosiers, Anik Forest, Gabrielle Boucher, Romain Ferru-Clément
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Disclosed are various lipid biomarkers of inflammatory bowel disease, including biomarkers for inflammatory bowel diseases including Crohn's disease and Ulcerative colitis. Also disclosed are various biomarkers of disease location and/or disease behavior in inflammatory bowel disease. The present disclosure also provides methods of using the biomarkers, including methods for diagnosis of inflammatory bowel disease, methods of determining predisposition to inflammatory bowel disease, methods of monitoring progression/regression of inflammatory bowel disease, and methods of assessing efficacy of compositions for treating inflammatory bowel disease.
A method for generating quantitative data for a subject consisting of determining a level of a set of biomarkers in a blood sample from the subject, wherein the set of biomarkers comprises 1) a phosphatidylethanolamine ether, 2) a sphingomyelin, 3) a cholesterol ester, 4) a very long-chain dicarboxylic acid (VLCDCA), and 5) sitosterol sulfate, and wherein the subject is suffering from an inflammatory bowel disease or is suspected of suffering from an inflammatory bowel disease.
Dependencies are inferred from the claim text.