US 12,754,184 B2 · Binding protein specific for the spike protein of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2)

Abstract

The present invention relates to novel proteins that specifically bind to the spike protein or domains thereof of the severe acute respiratory syndrome corona vims 2 (SARS-Cov-2) or variants of SARS-Cov-2. The proteins of the present invention represent advanced and powerful tools, for example for the purification of the virus or a vaccine for the virus, by virtue of said binding affinity for spike protein or domains of the spike protein of SARS-Cov-2 or variants thereof. Thus, the novel proteins of the present invention are particularly advantageous because they allow precise capturing of proteins or particles comprising spike proteins, S1 domain, and/or RBD in affinity chromatography. Further, the novel proteins of the present invention can be used in medical applications caused by or related to SARS-Cov-2 or variants thereof.

Claims19

Dependent claims

A binding protein for the spike protein of severe acute respiratory syndrome corona virus 2 (SARS-Cov-2) comprising any one of SEQ ID NOs:

1, 27, 28, and 65, wherein the binding protein has a binding affinity of less than 500 nM for the spike protein or domains thereof.

Dependencies are inferred from the claim text.

Facts

Application

18/012,281Filed 23 Jun 2021

Priority

EP 2018172523 Jun 2020

Published

US 2023/0272050 A131 Aug 2023

Granted

6 Oct 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

G01N 33/54373
Apparatus specially adapted for solid-phase testing: involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
C07K 1/22
By chromatography: affinity chromatography or related techniques based upon selective absorption processes
C07K 14/005
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from viruses
C07K 16/102
RNA viruses: coronaviridae

Binding protein specific for the spike protein of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2)

Life of this patent

Binding protein specific for the spike protein of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2)

Life of this patent

Abstract

Claims19