Hematological parameter for viral infection
AssigneeBeckman Coulter, Inc.
InventorYuxiao Du
Life of this patent
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Abstract
The disclosure relates to hematological parameters of viral infection. More specifically, the present disclosure relates to automated volume biomarkers lymph index and monocyte distribution width (MDW) for early detection of Coronavirus infection. The invention also relates to a method, device and computer executable program for early diagnosis of SARS-CoV-2 infection using volume biomarker lymph index and monocyte distribution width (MDW). According to some technical solutions of the present invention, the automated volumetric parameter lymph index and MDW can be used as viral biomarkers to help healthcare workers in the out-patient department or fever clinic to rapidly identify those who might be infected with SARS-CoV-2 and to provide valuable information for triage decision making.
Claims15
A method for identifying a subject having a viral infection, the method comprising:
- flowing a body fluid sample obtained from the subject through a flowcell;
- measuring individual cells of a plurality of cells in the body fluid sample;
- determining one or more cell population parameter data values in the body fluid sample based on the measuring, wherein the one or more cell population parameter data values comprise a population parameter data value from one or more of lymphocyte, neutrophil or monocyte;
- and
- determining whether or not at least one of the one or more cell population parameter data values exceeds a predetermined threshold,
- wherein if at least one of the one or more cell population parameter data values exceeds a predetermined threshold, the viral infection in the subject is indicated and
- wherein the viral infection is associated with an upper respiratory tract illness or a coronavirus infection.
A method for identifying a subject having a viral infection, the method comprising:
- flowing a body fluid sample obtained from the subject through a flowcell;
- measuring individual cells of a plurality of cells in the body fluid sample;
- determining one or more cell population parameter data values in the body fluid sample based on the measuring, wherein the one or more cell population parameter data values comprise a population parameter data value from one or more of lymphocyte, neutrophil or monocyte;
- and
- determining whether or not at least one of the one or more cell population parameter data values exceeds a predetermined threshold;
- wherein if at least one of the one or more cell population parameter data values exceeds a predetermined threshold, the viral infection in the subject is indicated;
- wherein the one or more cell population parameter data values comprises one or more selected from the group consisting of monocyte distribution width (MDW), lymphocyte volume (LV), lymphocyte distribution width (LV-SD), lymphocyte conductivity (LC), lymph index, mean neutrophil volume (MNV), neutrophil distribution width (NDW), or any combinations thereof;
- and
- wherein if the value of the MDW is greater than 20.27, the viral infection in the subject is indicated, or wherein if the value of the lymph index is greater than 11.3, the viral infection in the subject is indicated.
Dependencies are inferred from the claim text.