Back to results
US 12,753,417 B2Granted
Use of SARS-CoV-2 receptor binding motif (RBM)-reactive monoclonal antibodies to treat COVID-19
AssigneeThe Feinstein Institutes for Medical Research
InventorsHaichao Wang, Kevin J. Tracey, Jian Hua Li, Cassie Zhu, Xiaoling Qiang
Life of this patent
Estimating the term…
Abstract
Provided SARS-CoV-2 receptor binding motif (RBM)-reactive monoclonal antibodies and fragments thereof, which inhibit the interaction between the spike protein RBM and human ACE2, as well as methods of use employing such antibodies and/or fragments.
Claims18
A method of:
- (i) inhibiting binding of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) to an ACE2 receptor;
- (ii) inhibiting a SARS-COV-2 infection of, and/or SARS-COV-2-induced GM-CSF production in, a cell comprising an ACE2 receptor;
- or
- (iii) treating a subject for a SARS-COV-2 infection;
- comprising administering an amount of an antibody, or a SARS-COV-2 ACE2 Receptor Binding Motif (RBM)-binding fragment thereof, comprising
- a) a heavy chain variable region comprising:
- (SEQ ID NO:
- 21)
- TDYMS,
- (SEQ ID NO:
- 22)
- AINSNGGTTYYPDTVKG, and
- (SEQ ID NO:
- 23)
- QVKNGLDY;
- and a light chain variable region comprising:
- (SEQ ID NO:
- 24)
- RASQDISNYLN,
- (SEQ ID NO:
- 25)
- KTSRLHS, and
- (SEQ ID NO:
- 26)
- QQGNTLPPT;
- or
- b) a heavy chain variable region comprising:
- (SEQ ID NO:
- 27)
- SYYMS,
- (SEQ ID NO:
- 28)
- AINSNGGRTYYPDTVKG, and
- (SEQ ID NO:
- 29)
- QGKNGLDY;
- and a light chain variable region comprising:
- (SEQ ID NO:
- 30)
- RASQDISNHLN,
- (SEQ ID NO:
- 31)
- YTSRLHS, and
- (SEQ ID NO:
- 32)
- QQGKTLPPT;
- or
- c) a heavy chain variable region comprising:
- (SEQ ID NO:
- 33)
- SSYMS,
- (SEQ ID NO:
- 34)
- AINNNGGTTYYPDTVKG, and
- (SEQ ID NO:
- 35)
- QGKNGLDY;
- and a light chain variable region comprising:
- (SEQ ID NO:
- 36)
- RASQDIGNLLN,
- (SEQ ID NO:
- 37)
- YTSRLHS, and
- (SEQ ID NO:
- 38)
- QQANTLPPT;
- or
- d) a heavy chain variable region comprising:
- (SEQ ID NO:
- 39)
- SDYMS,
- (SEQ ID NO:
- 40)
- AINSNGGTTYYPDTVKG, and
- (SEQ ID NO:
- 41)
- QGKNGMDY;
- and a light chain variable region comprising:
- (SEQ ID NO:
- 42)
- RASQDISNHLN,
- (SEQ ID NO:
- 43)
- YTSRLHS, and
- (SEQ ID NO:
- 44)
- QQGKTLPPT.
85 more elements
Dependencies are inferred from the claim text.