Double-stranded RNAi agents for targeting and regulating HBV gene expression, and a use thereof

A double-stranded RNAi agent, wherein the double-stranded RNAi agent comprises an antisense strand and a sense strand complementary to the antisense strand forming a double-stranded region, wherein a nucleotide sequence of the antisense strand is a modified sequence of a sequence shown in SEQ ID NO:

• 8;
• wherein a nucleotide sequence of the sense strand is a modified sequence of a sequence shown in SEQ ID NO:
• 1;
• wherein the double-stranded RNAi agent comprises an oligonucleotide duplex selected from any one of the following sense and antisense strand pairs:
• (1) the sense strand has the sequence as shown in SEQ ID NO:
• 81, and the antisense strand has the sequence as shown in SEQ ID NO:
• 179, 180, 181, 182, or 184;
• (2) the sense strand has the sequence as shown in SEQ ID NO:
• 82, and the antisense strand has the sequence as shown in SEQ ID NO:
• 179, 180, or 183.