Back to results
US 12,753,393 B2Granted
Liquid crystal scaffolds and use thereof for organoid, spheroid, and 3D cellaggregate manufacturing
AssigneeThe Regents of the University of California
InventorsAmir Nasajpour, Paul S. Weiss, Ali Tamayol, Mohamadmahdi Samandari
Life of this patent
Estimating the term…
Abstract
The present invention provides liquid crystals and compositions thereof (e.g., liquid crystal-based scaffolds) for manufacturing various organoids, such as tumor organoids, as well as spheroids and/or 3D cell aggregates.
Claims19
A method of co-culturing at least one anchorage-dependent cell with at least one second cell, wherein the method comprises:
- coating a surface of a cell culture plate with a liquid crystal or composition thereof;
- co-culturing the at least one anchorage-dependent cell and the at least one second cell in the presence of the liquid crystal or a composition thereof;
- and
- inducing a phase change of the liquid crystal or composition thereof, thereby inducing cellular aggregation of the at least one anchorage-dependent cell and the at least one second cell.
1 more element
Dependencies are inferred from the claim text.