Composition for inducing direct cross differentiation of somatic cell into motor neuron, and method for using same

A method for direct conversion from a somatic cell into a motor neuron in vitro, the method comprising a step of bringing into contact with a somatic cell or of inserting into a somatic cell, a composition comprising:

• at least one direct conversion factor selected from the group consisting of an OCT4 protein, a nucleic acid molecule encoding the OCT4 protein operably linked to a promoter, and a vector into which the nucleic acid molecule encoding the OCT4 protein is introduced;
• and
• at least one additional direct conversion factor selected from the group consisting of a LHX3 protein, a nucleic acid molecule encoding the LHX3 protein, and a vector into which the nucleic acid molecule encoding the LHX3 protein is introduced,
• wherein the somatic cell is selected from the group consisting of a fibroblast, an epithelial cell, an oral epithelial cell, a hematopoietic stem cell, an umbilical cord blood stem cell, and a mesenchymal stem cell, and
• the vector comprises a viral vector selected from the group consisting of a lentiviral vector, a retrovirus vector, a human immunodeficiency virus (HIV) vector, a murineleukemia virus (MLV) vector, an adenovirus vector, and an adeno-associated virus vector.