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US 12,753,378 B2Granted
Device, a method and a system for dispersing cell clumps
AssigneeSuzhou Etta Biotech Co., Ltd.
InventorsEdward Dai, Shiying Zhu, Nan Qiao
Life of this patent
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Abstract
A cell clump dispersing device for dispersing cell clumps is provided, including a dispersion structure module that includes at least one structure for providing fluid flow shear force. Each structure for providing liquid flow shear force includes an inlet for cell clumps to be dispersed to enter the structure, and at least one outlet for dispersed cell clumps to flow out of the structure. A diameter of the outlet is smaller than that of the inlet, and an end of at least one of the structure is capable of being connected to an end of another of the structure.
Claims18
A cell clump dispersing device for dispersing cell clumps, comprising
- a dispersion structure module that includes at least one structure for providing fluid flow shear force, the at least one structure for providing fluid flow shear force comprising a first structure for providing liquid flow shear force and a second structure for providing liquid flow shear force that are series-connected along a flow direction of cell clumps to be dispersed, wherein each structure for providing liquid flow shear force comprises an inlet for cell clumps to be dispersed to enter the structure, and at least one outlet for dispersed cell clumps to flow out of the structure, a diameter of the at least one outlet is smaller than that of the inlet, each structure has a first end and a second end opposite to the first end, the first end of at least one of the structure is capable of being connected to the second end of another of the structure directly;
- wherein each structure for providing liquid flow shear force comprises a channel part with a proximal end and a distal end respectively located at opposite ends along a length extension direction of the channel part, and a narrowed part with a gradually decreased cross-sectional area in the structure for providing liquid flow shear force and with a first end and a second end respectively located at opposite ends along a length extension direction of the narrowed part, in each structure for providing liquid flow shear force, the distal end of the channel part is connected to the first end of the narrowed part, the proximal end of the channel part is the inlet, the second end of the narrowed part is the outlet, and an inner diameter of the narrowed part gradually decreases from the first end to the second end, an inner diameter of the channel part gradually decreases or remains unchanged from the proximal end to the distal end,
- the channel part of the second structure for providing liquid flow shear force is fixedly connected to an end of the first structure for providing liquid flow shear force away from the inlet of the first structure.
A cell clump dispersing device for dispersing cell clumps, comprising
- a dispersion structure module that includes at least one structure for providing fluid flow shear force, wherein each structure for providing liquid flow shear force comprises an inlet for cell clumps to be dispersed to enter the structure, and at least one outlet for dispersed cell clumps to flow out of the structure, a diameter of the at least one outlet is smaller than that of the inlet, each structure has a first end and a second end opposite to the first end, the first end of at least one of the structure is capable of being connected to the second end of another of the structure directly;
- wherein a side wall of the narrowed part close to the second end is provided with one or more structural weak portions.
A cell clump dispersing device for dispersing cell clumps, comprising
- a dispersion structure module that includes at least one structure for providing fluid flow shear force, wherein each structure for providing liquid flow shear force comprises an inlet for cell clumps to be dispersed to enter the structure, and at least one outlet for dispersed cell clumps to flow out of the structure, a diameter of the at least one outlet is smaller than that of the inlet, each structure has a first end and a second end opposite to the first end, the first end of at least one of the structure is capable of being connected to the second end of another of the structure directly;
- wherein the dispersion structure module further comprises a diverting device with at least one diverting inlet and at least two diverting outlets, and each of the diverting outlets is connected to the inlet of the structure for providing fluid flow shear force.
Dependencies are inferred from the claim text.