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US 12,753,271 B2Granted
Bio-functionalization of water-soluble poly(phenylene ehtylene)s
AssigneeBoard of Regents, The University of Texas System
InventorsDaniel Martinez, Han Sun, Zhiliang Li, Samantha Yee, April Risinger, Kirk Schanze
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Abstract
Certain embodiments are directed to the use of amide coupling chemistry to covalently link five different biofunctional groups onto an anionic water soluble poly(phenylene ethynylene) (PPE) polymer. Two of the biofunctionalized PPEs are used in prototype applications, including pH sensing and flow cytometry labeling.
Claims12
A water-soluble conjugated polymer comprising a base polymer coupled to one or more ligands, the conjugated polymer having a structure of Formula III
- wherein n can be any whole number between 2 and 500;
- A and B are aryl or heteroaryl;
- R1, R2, R3, and R4 are independently selected from a Cl to C12 alkoxy, Cl to C12 alkyl, or (CH2CH2O)m, where m is 2, 3, 4, 5, 6, 7, 8, 9, 10;
- X1 and X2 are carboxylic;
- X3 and X4 are sulfonic;
- and
- Y1, Y2, Y3, and Y4 can be H, or a detectable ligand, or therapeutic ligand, or a diagnostic ligand.
4 more elements
Dependencies are inferred from the claim text.