CD73-binding protein and use thereof
AssigneesShanghai Huaota Biopharmaceutical Co., Ltd., Huabo Biopharm (Shanghai) Co., Ltd.
InventorsJingen Xu, Xiangyang Zhu, Haijia Yu, Xiaoyue Wei, Lili Qu, Xiaochen Ren
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Abstract
Provided is an isolated antigen-binding protein, which can specifically bind to CD73 and includes at least one CDR in a heavy chain variable region VH, wherein the region VH includes an amino acid sequence as represented by SEQ ID NO: 49. Further provided are a preparation method for the isolated antigen-binding protein and the use thereof.
Claims11
An isolated antigen-binding protein, which is capable of specifically binding to a CD73 or a functionally active fragment thereof, comprising HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, and LCDR3, wherein said HCDR1 comprises an amino acid sequence as set forth in SEQ ID NO:
- 3, said HCDR2 comprises an amino acid sequence as set forth in SEQ ID NO:
- 2, said HCDR3 comprises an amino acid sequence as set forth in SEQ ID NO:
- 1, said LCDR1 comprises an amino acid sequence as set forth in SEQ ID NO:
- 6, said LCDR2 comprises an amino acid sequence as set forth in SEQ ID NO:
- 5, and said LCDR3 comprises an amino acid sequence as set forth in SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.