Agonist antibodies against endoglin and uses thereof
AssigneeThe Feinstein Institutes for Medical Research
InventorPhilippe Marambaud
Life of this patent
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Abstract
Provided are agonist anti-ENG coreceptor-specific antibodies and agonist anti-ENG coreceptor-binding fragments thereof, including antibodies that bind to the BMP9-binding region within an ectodomain of an ENG coreceptor, as well as methods of use employing such antibodies and/or fragments in treating diseases such as HHT and PAH.
Claims20
An isolated monoclonal antibody which binds to a human endoglin coreceptor, or an antigen-binding fragment of the monoclonal antibody, comprising
- a heavy chain variable region comprising:
- (SEQ ID NO:
- 3)
- GFTFNTYA;
- (SEQ ID NO:
- 4)
- IRSKSSNYAT;
- and
- (SEQ ID NO:
- 5)
- VRDRTGSWFAY;
- and a light chain variable region comprising:
- (SEQ ID NO:
- 6)
- QDIGSS;
- (SEQ ID NO:
- 7)
- ATS;
- and
- (SEQ ID NO:
- 8)
- LQYASSPYT.
An isolated ScFv encoded by the nucleotide sequence set forth in one of SEQ ID NOs:13, 14, 15 or 16, or an isolated ScFv comprising SEQ ID NO:17 and SEQ ID NO:18.
A composition comprising an isolated nucleic acid encoding a heavy chain variable region of an antibody which comprises:
- GFTENTYA (SEQ ID NO:3);
- IRSKSSNYAT (SEQ ID NO:4);
- and
- VRDRTGSWFAY (SEQ ID NO:5);
- and
- an isolated nucleic acid encoding a light chain variable region of the antibody which comprises:
- QDIGSS (SEQ ID NO:6);
- ATS (SEQ ID NO:7);
- and
- LQYASSPYT (SEQ ID NO:8)
- wherein the antibody binds human endoglin coreceptor.
An isolated monoclonal antibody which binds to a human endoglin coreceptor, or an antigen-binding fragment of the monoclonal antibody, comprising each CDR present in SEQ ID NO:17 and SEQ ID NO:18,
- wherein the antibody or antigen-binding fragment comprises
- a heavy chain variable region comprising:
- (SEQ ID NO:
- 3)
- GFTFNTYA;
- (SEQ ID NO:
- 4)
- IRSKSSNYAT;
- and
- (SEQ ID NO:
- 5)
- VRDRTGSWFAY;
- and a light chain variable region comprising:
- (SEQ ID NO:
- 6)
- QDIGSS;
- (SEQ ID NO:
- 7)
- ATS;
- and
- (SEQ ID NO:
- 8)
- LQYASSPYT.
Dependencies are inferred from the claim text.