Fusion protein comprising anti-CD3 single domain antibody, exosomal protein CD63 and RNA binding protein, and uses thereof
AssigneeChina Medical University Hospital
InventorsDer-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen, Yi-Wen Chen, Chung-Chun Wu, Kai-Wen Kan
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Abstract
The present disclosure provides a fusion protein including an anti-CD3 single domain antibody, an exosomal protein CD63 and an RNA binding protein. The fusion protein of the present disclosure achieves the effect of treating cancer, immunoregulation and activating immune cells through various efficacy experiments.
Claims18
A fusion protein, comprising an anti-CD3 single domain antibody, an exosomal protein, and an RNA binding protein, wherein the amino acid sequence of the anti-CD3 single domain antibody is a heavy chain variable domain (VHH) sequence comprising SEQ ID NO:
- 2, and the exosomal protein is CD63.
Dependencies are inferred from the claim text.