Compositions and methods for modulating FLRT3 mediated signal transduction
AssigneeNextcure, Inc.
InventorsDallas Benjamin Flies, Kushal Prajapati, Adem Can Koksal, Linda Liu, Solomon Langermann
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Abstract
Compositions and methods of use thereof for modulating FLRT3 mediated signaling are provided. For example, immunomodulatory agents are provided that reduce FLRT3 expression, ligand binding, crosslinking, FLRT3 mediated signaling, or a combination thereof. In another embodiment, immunomodulatory agents are provided that enhance or promote FLRT3 expression, ligand binding, crosslinking, FLRT3 mediated signaling, or a combination thereof. Such agents can be used to modulate an immune response in a subject in need thereof.
Claims9
An anti-FLRT3 antibody or antigen-binding fragment thereof comprising:
- a) a light chain variable region comprising SEQ ID NO:
- 17, and
- b) a heavy chain variable region comprising SEQ ID NO:
- 50
- wherein the antibody of antigen-binding fragment thereof binds to FLRT3.
Dependencies are inferred from the claim text.